As far as I am aware, it should work OK.
JuiceboxBuilder-Pro is a 64-bit application on a Mac so there should be no issues in that regard (i.e. with 32-bit applications no longer being supported).

If you are using an M1 Mac, please try the suggestion here (to use Rosetta): https://juicebox.net/forum/viewtopic.ph … 104#p18104

Also, check out the Known Issues on the AIR download page (https://airsdk.harman.com/runtime) as the Known Issue relating to the Encrypted Local Store is relevant to JuiceboxBuilder-Pro on a Mac.

If none of the above helps, please let me know more about the problem that you are experiencing and I might be able to help further.
Is the problem with installing AIR and/or JuiceboxBuilder-Pro or are you able to install both programs OK but are unable to run JuiceboxBuilder-Pro afterwards?
Do you encounter any error messages along the way? If so, what do they say.

I've heard of one Mac user who was unable to run JuiceboxBuilder-Pro under their regular user account but it worked after creating a new administrator user account and installing JuiceboxBuilder-Pro under the new user profile so this might be worth trying, too.

Edit:
Yes, we have confirmed reports of Monterey users running JuiceboxBuilder successfully.
If you have M1 hardware, you might need to use Rosetta (as noted above and also in the Known Issues section of the AIR runtime download page.